Restorative Sleep is the Foundation of Health
When you miss out on deep, restorative sleep, it doesn’t just make you tired. Over time, it can quietly chip away at your heart health, metabolism, mood, immunity, and even how long you live.
Healthy sleep helps regulate blood pressure, heart rate, and vascular function.
Sleeping less than 7 hours per night is linked with higher risk of hypertension, coronary heart disease, stroke, and cardiovascular events in large cohort and meta‑analysis studies.
Good sleep helps balance the hormones that control your appetite and blood sugar.
With chronic short sleep, your body is more likely to crave high‑calorie foods, gain weight, and develop insulin resistance and type 2 diabetes as multiple reviews link short sleep to obesity and diabetes risk.
Deep sleep is when your brain files memories, clears waste, and restores emotional balance.
When you’re underslept, you’re more likely to feel anxious, low, forgetful, and unfocused, and your long‑term risk of mood disorders and cognitive problems increases as systematic reviews show sleep loss worsens anxiety, depression, and memory.
Quality sleep strengthens your immune system and helps calm chronic inflammation.
If you live in a state of ongoing sleep debt, you’re more likely to get sick, stay sick longer, and face a higher risk of serious long‑term health issues, including earlier death from all causes as shown in meta‑analyses of sleep duration and all‑cause mortality.
TruCBN is Your Key to Restorative Sleep
TruCBN is an ultra-pure form of cannabinol (CBN) — a naturally occurring, non-intoxicating cannabinoid found in hemp plants.
This compound naturally helps you fall asleep more easily, stay asleep, and wake up clear‑headed.
TruCBN softgels are designed for adults who want reliable sleep support without feeling “knocked out” or relying on a nightly hormone.
How does TruCBN works in your body?
Your body has an endocannabinoid system that helps regulate alertness and calm. CBN interacts with this system by binding to CB1 and CB2 receptors. But unlike THC, it binds weakly to CB1, so it supports sleep without intoxication.
TruCBN also works through additional pathways: it activates TRP channels (involved in pain and temperature regulation), influences GABA (a calming neurotransmitter), and modulates the orexin system, which controls wakefulness.
By gently reducing orexin-driven arousal, TruCBN helps you stay asleep through the night and wake up restored, rather than simply knocking you out or disrupting natural sleep cycles.
How TruCBN helps you stay asleep
For many people, the real issue isn’t falling asleep. It’s waking up at 2 a.m. and struggling to get back to sleep.
The research, including our clinical trial, shows that TruCBN is especially promising for this sleep maintenance problem, helping to reduce nighttime awakenings and improve overall sleep quality.
That’s why TruCBN is built around CBN instead of melatonin. By working with the systems that regulate arousal and relaxation rather than replacing a hormone, TruCBN is designed to support deeper, more continuous sleep, without the groggy “sleep hangover”, dependency and other issues common with many sleep aids.
We wanted to know if TruCBN actually works, so we ran a large, independent clinical trial. Over 1,000 adults with sleep issues took either TruCBN, melatonin, or placebo every night for four weeks. Here's what happened.
The Study Design
The Results
Why It Matters
Most sleep supplements never get tested like this. We ran a proper clinical trial because we wanted evidence, not just testimonials.
The results show that TruCBN can genuinely help adults sleep better, particularly at the 50 mg dose we use in our softgels.
Safety & Purity: What’s in (and not in) TruCBN
TruCBN is the only CBN that has undergone full GLP safety testing to FDA‑level standards for dietary ingredients.
More Research on CBN and Sleep
The TruCBN clinical trial is part of a broader, fast‑growing body of research on CBN and sleep. Here are some of the key studies scientists are using to understand how CBN affects sleep quality, nighttime awakenings, and next‑day function.
Click on any of the studies below to get more information.
CBN With and Without CBD for Sleep Quality (Bonn‑Miller et al., 2024)
In this trial, adults with self‑reported poor sleep took 20 mg CBN, CBN + CBD, or placebo nightly for seven days.
CBN, with or without CBD, led to a statistically significant reduction in nighttime awakenings and overall sleep disturbance compared to placebo, but did not significantly change time to fall asleep or next‑day fatigue. The study found CBN was well tolerated, with no serious adverse events.
Importantly, in this study, adding CBD to CBN did not improve sleep outcomes compared to CBN alone.
See the study ↗
01
High‑Dose CBN and Objective Sleep (Lavender et al., 2023 Protocol)
The CUPID trial is an ongoing in‑lab study in adults with diagnosed insomnia disorder. Participants receive single oral doses of 30 mg and 300 mg CBN or placebo in a cross‑over design, with detailed polysomnography (sleep lab) recordings.
The main outcome is wake after sleep onset (WASO), with secondary endpoints including sleep onset latency, sleep stages, next‑day driving simulation, and cognitive performance. Results are pending, but this trial will provide some of the first high‑quality objective sleep data for CBN.
See the Study ↗
02
Cannabinoids and Sleep Disorders Review (Lavender et al., 2022)
This review summarizes the state of evidence for cannabinoids in insomnia and other sleep disorders, including early data on CBN.
The authors conclude that CBN shows emerging potential for sleep maintenance (reducing awakenings) with a generally favorable safety profile, but they highlight the need for more large, controlled trials with objective sleep measures. TruCBN and CUPID‑style studies are examples of the newer work they call for.
See the Study ↗
03
CBD, CBN, and Melatonin Combinations for Sleep (Saleska et al., JANA, 2024)
In this 6‑arm randomized, double‑blind study with 1,793 adults reporting sleep disturbance, researchers tested different combinations of CBD, CBN, and melatonin over four weeks.
Several cannabinoid‑based formulas improved self‑reported sleep disturbance compared to baseline, but low‑dose CBN added to CBD did not consistently outperform CBD or melatonin alone. Overall, non‑intoxicating cannabinoid formulations were well tolerated, with no serious safety concerns.
See the Study ↗
04
Cannabinoids and Sleep Architecture in Animal Models (Low et al., 2023)
This preclinical review looks at how different cannabinoids, including CBN, affect sleep architecture in animal models. Across studies, CBN is associated with increased non‑REM sleep and changes in REM patterns, consistent with a potential role in improving sleep maintenance rather than simply inducing sedation.
The paper also highlights cannabinoid interactions with thermoregulation and circadian processes, which can influence how stable and continuous sleep feels.
See the Study ↗
05
Cannabinoid–Orexin Interactions and Arousal (Kim et al., 2021)
This study explores how cannabinoid receptors and orexin receptors interact in specific brain regions that control arousal and wakefulness. The authors show that cannabinoid and orexin signaling can converge and modulate each other, providing biological plausibility for CBN’s ability to reduce hyper‑arousal at night without broad, sedating effects.
While not a CBN sleep trial, it supports the idea that cannabinoids can influence wake–sleep regulation through orexin pathways.
See the Study ↗
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Learn More
Start Sleeping
TruCBN is the key to restorative sleep, ensuring you fall asleep faster and stay asleep longer.
